DRD-medshortnote

Welcome to DRD- medsortrnote. Today we will discuss about Paracetamol.      This topic includes :- General properties & Mechanism of action Dosage Use Adverse reactions Toxicity, Clinical features & How to Manage Paracetamol toxicity  1) GENERAL PROPERTIES AND MECHANISM OF ACTION :- General properties:- Paracetamol / N-acetyl P-aminophenol / Acetaaminophene is classified under group of drugs called Para-aminophenol derivatives under Major group called NSAIDs Non Steroidal Anti Inflammatory Drugs. Acetanilide is the parent member of this group of drug. it was first used in medicine by Von Mering in 1893. Peak plasma concentration Cp = In ½ to 1 hour.   t ½ is 2hours Protein binding is 20 to 50% Metabolized by Glucuronides (60%) and Sulfates (35%) Mechanism of Action :-  It has both Anti Pyretic and Anti Inflammatory activity. but Anti pyretic effect is more pronounced. M.O.A.:- weak Nonspecific COX (Cyclooxygenase) enzyme inhibition by...

Welcome to DRD medshortnote.   Today we will discuss about MUCORMYCOSIS :- This topic contains :- Microbiology of mucormycosis Pathophyiology of disease caused by it Clinical features  Diagnosis and investigations  Management 1) MUCORMYCOSIS MICROBIOLOGY : Mucormycosis is caused by Fungi - order Mucorales of subphylum mucormycotina. All Fungi are classified morphologically into 4 major classes :- Yeasts Yeast like Molds Dimorphic Mucorales comes under MOLDS ( ASEPTATE MOLDS ) mucorales includes : Rhizopus ( most common cause) { R.oryzae & R. delemar } Mucor  Rhizo mucor  Cunninghamella Lichtheimia   image showing aseptate broad hyphae seen under microscope in gomori methenemine silver stain.  schematic diagram of asexual form of Rhizopus fungi 2) PATHOPHYSIOLOGY OF MUCORMYCOSIS : - Mucorales are ubiquitous organism but it is present mainly in humid atmosphere, dust, in kitchen garbage, in soil, on rotten bread, etc. Causes infection in - Diabetic...