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ART ( ANTI RETROVIRAL THERAPY ) regimen in children (simplified)

 📙BASIC RULES IN A.R.T. ( Anti Retroviral Therapy ) for children; according to NACO ( National Aids Control Organisation ) guidelines : 


❶ In child <3 years EFV ( Efavirenz ) is not given. So, it is replaced by LPV/r Lopinavir boosted combination.

❷ In <10 years old child TDF ( Tenofovir ) is not given. So, it is replaced by ABC ( Abacavir )

❸ In case of Anemia - AZT ( Zidovudin ) is not given. So, it is replaced by ABC ( Abacavir )

❹ In case of Child with Renal disease - TDF ( Tenofovir ) is not given. So it is replaced with ABC ( Abacavir)

 

📙 Basic formula is : 3TC + TDF + EFV

  • 3TC = Lamivudin
  • TDF = Tenofovir
  • EFV = Efavirenz
  • AZT = Zidovudin
  • ABC = Abacavir
  • LPV/r = Lopinavir ( ritonavir boosted ) 

 

 

①ART REGIMEN IN CHILD <3 YEARS AGE :-

  • EFV replaced with LPV/r
  • TDF replaced with AZT
  • In Anemia AZT is replaced with ABC

AGE (Years)

 

<3 years

 

 

 

Hb (%)

<9 %

Hb

>9 %

Hb


 

 

 

Regime

3TC

3TC

ABC

AZT

LPV/r

LPV/r

 

 

②ART REGIMEN IN CHILD AGED BETWEEN 3 TO 10 YEARS :-

  • In Anemia AZT is replaced with ABC

AGE (Years)

 

3 to 10 years

 

 

 

Hb (%)

<9 %

Hb

>9 %

Hb


 

 

 

Regime

3TC

3TC

ABC

AZT

EFV

EFV

 

 

③ART REGIMEN IN CHILD AGED >10 YEARS :- 

  •  In Abnormal Renal conditions TDF is replaced with ABC

AGE (Years)

 

 >10 years

 

 

 

Weight

< 30 kg

> 30 kg

S. CREATININ

ABNORMAL

Renal function

NORMAL

Renal function

 

 

 

 

Regime

Follow 3 to 10 Years regime

3TC

3TC

ABC

TDF

EFV

EFV

 

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